The association between high-sensitivity C-reactive protein and metabolic risk factors in black and white South African women: a cross-sectional study

George, Cindy; Evans, Juliet; Micklesfield, Lisa K.; Olsson, Tommy; Goedecke, Julia H.

doi:10.1186/s40608-018-0191-7

Table 3 Adjusted associations between log-transformed metabolic risk factors, insulin resistance [HOMA-IR (units)] and serum lipids (TG, TC, HDL-C and LDL-C (mmol/l)), and hsCRP (μg/ml) in black and white South African women

From: The association between high-sensitivity C-reactive protein and metabolic risk factors in black and white South African women: a cross-sectional study

Variables	Model 1	Model 2	Model 3
ln(HOMA-IR)	β [95% CI]	β [95% CI]	β [95% CI]
hsCRP	0.09 [0.05; 0.13]**	0.10 [0.06; 0.14]**	0.03 [−0.01; 0.07]
Age	−0.01 [− 0.02; 0.00]	− 0.01 [− 0.02; 0.00]	− 0.02 [− 0.03; − 0.01]**
Race/ethnicity	0.26 [0.03; 0.48]*	0.00 [− 0.27; 0.27]	− 0.00 [− 0.23; 0.23]
hsCRPxrace/ethnicity	− 0.02 [− 0.07; 0.04]	−0.04 [− 0.09; 0.02]	−0.02 [− 0.07; 0.02]
Adjusted-R ²	0.11**	0.15**	0.38**
ln(TG)	β [95% CI]	β [95% CI]	β [95% CI]
hsCRP	0.07 [0.05; 0.10]**	0.06 [0.04; 0.09]**	0.04 [0.02; 0.07]**
Age	0.01 [0.00; 0.01]*	0.01 [0.00; 0.02]*	0.01 [−0.00; −0.00]
Race/ethnicity	−0.04 [− 0.18; 0.10]	−0.14 [− 0.30; 0.03]	−0.14 [− 0.30; 0.02]
hsCRPxrace/ethnicity	− 0.05 [− 0.09; − 0.02]*	−0.05 [− 0.08; − 0.01]*	−0.04 [− 0.08; − 0.01]*
Adjusted-R ²	0.18**	0.20**	0.26**
ln(TC)	β [95% CI]	β [95% CI]	β [95% CI]
hsCRP	0.02 [0.01; 0.03]*	0.02 [0.00; 0.03]*	0.01 [−0.00; 0.02]
Age	0.00 [0.00; 0.01]*	0.01 [0.00; 0.01]**	0.01 [0.00; 0.01]**
Race/ethnicity	−0.05 [− 0.11; 0.02]	−0.04 [− 0.12; 0.03]	−0.04 [− 0.12; 0.03]
hsCRPxrace/ethnicity	− 0.04 [− 0.06; − 0.03]**	−0.03 [− 0.05; − 0.02]**	−0.03 [− 0.05; − 0.01]**
Adjusted-R ²	0.26**	0.29**	0.30**
ln(HDL-C)	β [95% CI]	β [95% CI]	β [95% CI]
hsCRP	−0.01 [− 0.03; − 0.01]*	−0.02 [− 0.03; − 0.00]*	−0.00 [− 0.02; 0.01]
Age	− 0.00 [− 0.01; 0.00]	−0.00 [− 0.00; 0.00]	0.00 [− 0.00; 0.01]
Race/ethnicity	−0.16 [− 0.25; − 0.07]**	−0.01 [− 0.12; 0.09]	−0.03 [− 0.13; 0.08]
hsCRPxrace/ethnicity	− 0.03 [− 0.05; − 0.01]*	−0.02 [− 0.04; 0.01]	−0.02 [− 0.04; 0.00]
Adjusted-R ²	0.22**	0.34**	0.39**
ln(LDL-C)	β [95% CI]	β [95% CI]	β [95% CI]
hsCRP	0.03 [0.01; 0.05]*	0.02 [−0.00; 0.04]*	0.01 [−0.02; 0.03]
Age	0.01 [−0.00; 0.01]	0.01 [0.00; 0.12]*	0.01 [−0.00; 0.01]
Race/ethnicity	−0.02 [− 0.14; 0.09]	−0.14 [− 0.29; 0.01]	−0.13 [− 0.27; 0.02]
hsCRPxrace/ethnicity	− 0.04 [− 0.07; − 0.01]*	−0.03 [− 0.06; 0.00]	−0.03 [− 0.06; 0.00]
Adjusted-R ²	0.08**	0.15**	0.19**

Data represents β-coefficients [95% confidence interval] and adjusted-R². Model 1: hsCRP + age + race/ethnicity + (hsCRP x race/ethnicity interaction); Model 2: (Model 1) + SES + lifestyle factors; Model 3: (Model 2) + WC. hsCRP, C-reactive protein; interaction term, interaction between hsCRP and race/ethnicity; ln(HOMA-IR), ln(TG), natural log of triglycerides; natural log of homeostatic model assessment; ln(TC), natural log of total cholesterol; ln(HDL-C), natural log of high-density lipoprotein cholesterol; ln(LDL-C), natural log of low-density lipoprotein cholesterol. *p < 0.05 and **p < 0.001

Back to article page

ISSN: 2052-9538

Contact us

General enquiries: ORSupport@springernature.com

BMC Obesity

Contact us