Basic science, physiology, genetics, phenotyping and metabolism

Section edited by Philip McTernan

This section considers studies on all aspects of the underlying biological aspects of obesity in the body, including genetics, hormone interactions, lipid metabolism, adipocyte physiology and function, and metabolic dysfunction and disease risk.

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  1. Research article

    Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults

    Resting metabolic rates (RMR) vary across individuals. Understanding the determinants of RMR could provide biological insight into obesity and its metabolic consequences such as type 2 diabetes and cardiovascu...

    Jacklyn N. Hellwege, Digna R. Velez Edwards, Sari Acra, Kong Chen, Maciej S. Buchowski and Todd L. Edwards

    BMC Obesity 2017 4:12

    Published on: 5 April 2017

  2. Research article

    Metabolic improvements following Roux-en-Y surgery assessed by solid meal test in subjects with short duration type 2 diabetes

    Glucose homeostasis improves within days following Roux-en-Y gastric bypass (RYGB) surgery. The dynamic metabolic response to caloric intake following RYGB has been assessed using liquid mixed meal tolerance t...

    Sudha S. Shankar, Lori A. Mixson, Manu Chakravarthy, Robin Chisholm, Anthony J. Acton, RoseMarie Jones, Samer G. Mattar, Deborah L. Miller, Lea Petry, Chan R. Beals, S. Aubrey Stoch, David E. Kelley and Robert V. Considine

    BMC Obesity 2017 4:10

    Published on: 1 March 2017

  3. Research article

    Somatic neural alterations in non-diabetic obesity: a cross-sectional study

    Reports on alterations in somatic neural functions due to non-diabetic obesity, a major risk factor for diabetes, are few and still a matter of debate. Nevertheless, to our knowledge, reports lack any comments...

    Ram Lochan Yadav, Deepak Sharma, Prakash Kumar Yadav, Dev Kumar Shah, Kopila Agrawal, Rita Khadka and Md. Nazrul Islam

    BMC Obesity 2016 3:50

    Published on: 22 November 2016

  4. Technical advance

    Adipocyte nuclei captured from VAT and SAT

    Obesity-related comorbidities are thought to result from the reprogramming of the epigenome in numerous tissues and cell types, and in particular, mature adipocytes within visceral and subcutaneous adipose tis...

    Suresh Ambati, Ping Yu, Elizabeth C. McKinney, Muthugapatti K. Kandasamy, Diane Hartzell, Clifton A. Baile and Richard B. Meagher

    BMC Obesity 2016 3:35

    Published on: 19 July 2016

  5. Research article

    Correlation of adiposity indices with cardiovascular disease risk factors in healthy adults of Singapore: a cross-sectional study

    Obesity has long been highlighted for its association with increased incidence of cardiovascular disease (CVD). Nonetheless, the best adiposity indices to evaluate the CVD risk factors remain contentious and f...

    Xinyan Bi, Siew Ling Tey, Claudia Leong, Rina Quek, Yi Ting Loo and Christiani Jeyakumar Henry

    BMC Obesity 2016 3:33

    Published on: 7 July 2016

  6. Research article

    Maternal obesity (Class I-III), gestational weight gain and maternal leptin levels during and after pregnancy: a prospective cohort study

    Maternal obesity is accompanied by maternal and fetal complications during and after pregnancy. The risks seem to increase with degree of obesity. Leptin has been suggested to play a role in the development of...

    Sara Carlhäll, Marie Bladh, Jan Brynhildsen, Ing-Marie Claesson, Ann Josefsson, Gunilla Sydsjö, Annika Thorsell and Marie Blomberg

    BMC Obesity 2016 3:28

    Published on: 20 May 2016

  7. Research article

    The Pro12Ala polymorphism in the PPAR-γ2 gene is not associated to obesity and type 2 diabetes mellitus in a Cameroonian population

    Peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) is a transcription factor with a key role in adipocyte differentiation, lipid storage and glucose homeostasis. The Ala allele of the common Pro12Ala po...

    Edith Pascale M. Mato, Priscille Eunice Pokam-Fosso, Barbara Atogho-Tiedeu, Jean Jacques N. Noubiap, Marie-Solange Evehe, Rosine Djokam-Dadjeu, Olivier Sontsa Donfack, Elvis Ndonwi Ngwa, Magellan Guewo-Fokeng, Wilfred F. Mbacham, Eugene Sobngwi and Jean Claude Mbanya

    BMC Obesity 2016 3:26

    Published on: 12 May 2016

  8. Research article

    Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis in a large cohort of female patients

    Obesity is a risk factor for breast cancer in postmenopausal women and is associated with decreased survival and less favorable clinical characteristics such as greater tumor burden, higher grade, and poor pro...

    Allyson L. Toro, Nicholas S. Costantino, Craig D. Shriver, Darrell L. Ellsworth and Rachel E. Ellsworth

    BMC Obesity 2016 3:22

    Published on: 29 April 2016

  9. Research article

    A single oral dose of a polyglucosamine influences the bioavailability of [9-14C]-Oleic acid in adult female Göttingen minipigs

    Worldwide obesity has nearly doubled since 1980 and is a leading risk for global deaths, profoundly affecting morbidity, mortality, health-care costs, and professional and personal quality of life. Treatment o...

    Nicole H. P. Cnubben, Shanti L. Tel, Marleen A. Hemmes, Astrid Langenkamp-Brand, Dimitri Grossouw, Harm T. Jansen and Bert T. H. J. de Bie

    BMC Obesity 2016 3:18

    Published on: 15 March 2016

  10. Research article

    Metabolic endotoxaemia in childhood obesity

    Childhood obesity is associated with chronic low-grade inflammation considered as a precursor to metabolic disease; however, the underlying mechanisms for this remain unclear. Studies in adults have implicated...

    Madhusudhan C. Varma, Christine M. Kusminski, Sahar Azharian, Luisa Gilardini, Sudhesh Kumar, Cecilia Invitti and Philip G. McTernan

    BMC Obesity 2016 3:3

    Published on: 27 January 2016

  11. Research article

    Intima-media thickness and arterial function in obese and non-obese children

    Obesity is an independent cardiovascular risk factor that contributes to the development of atherosclerosis. Subclinical forms of the disease can be assessed via sonographic measurement of carotid intima-media...

    Heidi Weberruß, Raphael Pirzer, Birgit Böhm, Robert Dalla Pozza, Heinrich Netz and Renate Oberhoffer

    BMC Obesity 2016 3:2

    Published on: 9 January 2016

  12. Research article

    Gene expression of the zinc transporter ZIP14 (SLC39a14) is affected by weight loss and metabolic status and associates with PPARγ in human adipose tissue and 3T3-L1 pre-adipocytes

    The expansion and function of adipose tissue are important during the development of insulin resistance and inflammation in obesity. Zinc dyshomeostasis is common in obese individuals. In the liver, zinc influ...

    Trine Maxel, Kamille Smidt, Agnete Larsen, Marianne Bennetzen, Karina Cullberg, Karen Fjeldborg, Sten Lund, Steen B. Pedersen and Jørgen Rungby

    BMC Obesity 2015 2:46

    Published on: 24 November 2015

  13. Research article

    Plasma branched-chain and aromatic amino acid concentration after ingestion of an urban or rural diet in rural Mexican women

    People living in rural areas are prone to move to urban cities experiencing a dramatic change in the type of protein consumed. However, it is not know if those changes are associated with changes in the plasma...

    Adriana M López, Lilia G Noriega, Margarita Diaz, Nimbe Torres and Armando R Tovar

    BMC Obesity 2015 2:8

    Published on: 22 February 2015

  14. Research article

    Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency

    The potential health effects of polybrominated diphenyl ethers (PBDEs) that are widely used as flame-retardants in consumer products have been attributed, in part, to their endocrine disrupting properties. The...

    Rebecca L McIntyre, Heidi L Kenerson, Savitha Subramanian, Shari A Wang, Machiko Kazami, Heather M Stapleton and Raymond S Yeung

    BMC Obesity 2015 2:3

    Published on: 7 February 2015

  15. Research article

    Altered NK cell function in obese healthy humans

    Obesity is associated with an elevated risk for several types of cancer and thus a major health hazard. However, the mechanism between overweight and cancer susceptibility is still elusive. Leptin, mainly prod...

    Tobias Laue, Christiane D Wrann, Birgit Hoffmann-Castendiek, Daniel Pietsch, Lena Hübner and Heike Kielstein

    BMC Obesity 2015 2:1

    Published on: 24 January 2015

  16. Research article

    Moderate intensity physical activity prevents increased blood glucose concentrations, fat pad deposition and cardiac action potential prolongation following diet-induced obesity in a juvenile-adolescent rat model

    Both obesity and a lack of physical activity have been associated with an elevated risk of cardiovascular disease (CVD). The incidence of obesity is increasing, especially in juvenile-adolescents. While there ...

    Alannah van Waveren, Mitch J Duncan, Fiona R Coulson and Andrew Fenning

    BMC Obesity 2014 1:11

    Published on: 20 August 2014

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