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Table 1 Average oxygen consumption (VO 2 ), carbon dioxide production (VCO 2 ), respiratory exchange ratio (RER), heat production, motor activity, food consumption at week 10 of treatment and food consumption at week 28 of treatment

From: Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet

  Prevention Reversal
  HFD HFD HFD Normal HFD HFD HFD
CO-28 CO-200 Control Control CO-28 CO-200 Control
(n = 4) (n = 4) (n = 4) (n = 4) (n = 4) (n = 4) (n = 4)
VO2 (ml/kg/min) 54.2 ± 8.2 50.3 ± 8.1 55.6 ± 2.8 61.5 ± 5.7 56.5 ± 12.4 55.8 ± 8.8 52.7 ± 8.7
VCO2 (ml/kg/min) 40.3 ± 6.5 37.0 ± 7.3 40.7 ± 2.4 46.0 ± 4.4 41.2 ± 9.6 40.7 ± 6.5 39.1 ± 7.5
RER 0.73 ± 0.02 0.73 ± 0.04 0.73 ± 0.02 0.74 ± 0.02 0.73 ± 0.03 0.73 ± 0.01 0.74 ± 0.02
Heat Prod. (Cal/hr) 826 ± 135 797 ± 105 857 ± 43 605 ± 68* 828 ± 168 912 ± 158 883 ± 84
Motor Act. (m/day) 3.88 ± 0.90 3.39 ± 0.56 4.44 ± 1.84 8.87 ± 1.51* 4.52 ± 2.15 6.76 ± 3.24 3.77 ± 2.94
Food 10 weeks (g/day) 2.8 ± 0.1 2.5 ± 0.2 2.2 ± 0.1# 3.2 ± 0.8 3.7 ± 0.4 3.0 ± 0.1 3.2 ± 0.4
Food 28 weeks (g/day) 3.0 ± 0.2 3.0 ± 0.4 3.3 ± 0.8 3.4 ± 0.3 3.2 ± 0.2 3.4 ± 0.3 3.2 ± 0.3
  1. Data are mean ± SD. *Significant from all HFD groups, p < 0.05. #Significant for normal diet control, p < 0.05.
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