| |
Prevention
|
Reversal
|
|---|
| |
HFD
|
HFD
|
HFD
|
Normal
|
HFD
|
HFD
|
HFD
|
|---|
|
CO-28
|
CO-200
|
Control
|
Control
|
CO-28
|
CO-200
|
Control
|
|---|
|
(n = 4)
|
(n = 4)
|
(n = 4)
|
(n = 4)
|
(n = 4)
|
(n = 4)
|
(n = 4)
|
|---|
|
VO2 (ml/kg/min)
|
54.2 ± 8.2
|
50.3 ± 8.1
|
55.6 ± 2.8
|
61.5 ± 5.7
|
56.5 ± 12.4
|
55.8 ± 8.8
|
52.7 ± 8.7
|
|
VCO2 (ml/kg/min)
|
40.3 ± 6.5
|
37.0 ± 7.3
|
40.7 ± 2.4
|
46.0 ± 4.4
|
41.2 ± 9.6
|
40.7 ± 6.5
|
39.1 ± 7.5
|
|
RER
|
0.73 ± 0.02
|
0.73 ± 0.04
|
0.73 ± 0.02
|
0.74 ± 0.02
|
0.73 ± 0.03
|
0.73 ± 0.01
|
0.74 ± 0.02
|
|
Heat Prod. (Cal/hr)
|
826 ± 135
|
797 ± 105
|
857 ± 43
|
605 ± 68*
|
828 ± 168
|
912 ± 158
|
883 ± 84
|
|
Motor Act. (m/day)
|
3.88 ± 0.90
|
3.39 ± 0.56
|
4.44 ± 1.84
|
8.87 ± 1.51*
|
4.52 ± 2.15
|
6.76 ± 3.24
|
3.77 ± 2.94
|
|
Food 10 weeks (g/day)
|
2.8 ± 0.1
|
2.5 ± 0.2
|
2.2 ± 0.1#
|
3.2 ± 0.8
|
3.7 ± 0.4
|
3.0 ± 0.1
|
3.2 ± 0.4
|
|
Food 28 weeks (g/day)
|
3.0 ± 0.2
|
3.0 ± 0.4
|
3.3 ± 0.8
|
3.4 ± 0.3
|
3.2 ± 0.2
|
3.4 ± 0.3
|
3.2 ± 0.3
|
- Data are mean ± SD. *Significant from all HFD groups, p < 0.05. #Significant for normal diet control, p < 0.05.
