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Table 1 Average oxygen consumption (VO 2 ), carbon dioxide production (VCO 2 ), respiratory exchange ratio (RER), heat production, motor activity, food consumption at week 10 of treatment and food consumption at week 28 of treatment

From: Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet

 

Prevention

Reversal

 

HFD

HFD

HFD

Normal

HFD

HFD

HFD

CO-28

CO-200

Control

Control

CO-28

CO-200

Control

(n = 4)

(n = 4)

(n = 4)

(n = 4)

(n = 4)

(n = 4)

(n = 4)

VO2 (ml/kg/min)

54.2 ± 8.2

50.3 ± 8.1

55.6 ± 2.8

61.5 ± 5.7

56.5 ± 12.4

55.8 ± 8.8

52.7 ± 8.7

VCO2 (ml/kg/min)

40.3 ± 6.5

37.0 ± 7.3

40.7 ± 2.4

46.0 ± 4.4

41.2 ± 9.6

40.7 ± 6.5

39.1 ± 7.5

RER

0.73 ± 0.02

0.73 ± 0.04

0.73 ± 0.02

0.74 ± 0.02

0.73 ± 0.03

0.73 ± 0.01

0.74 ± 0.02

Heat Prod. (Cal/hr)

826 ± 135

797 ± 105

857 ± 43

605 ± 68*

828 ± 168

912 ± 158

883 ± 84

Motor Act. (m/day)

3.88 ± 0.90

3.39 ± 0.56

4.44 ± 1.84

8.87 ± 1.51*

4.52 ± 2.15

6.76 ± 3.24

3.77 ± 2.94

Food 10 weeks (g/day)

2.8 ± 0.1

2.5 ± 0.2

2.2 ± 0.1#

3.2 ± 0.8

3.7 ± 0.4

3.0 ± 0.1

3.2 ± 0.4

Food 28 weeks (g/day)

3.0 ± 0.2

3.0 ± 0.4

3.3 ± 0.8

3.4 ± 0.3

3.2 ± 0.2

3.4 ± 0.3

3.2 ± 0.3

  1. Data are mean ± SD. *Significant from all HFD groups, p < 0.05. #Significant for normal diet control, p < 0.05.