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Table 1 Morphological features of BAT, WAT and BeAT

From: Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity

Cell shape Variable, but classically spherical Polygonal Resembles WAT
Cell size Variable, but large (25-200 μm) Comparatively small (15-60 μm) Variable
Nucleus Peripheral, flattened Central, round or oval in shape To be determined
Cytoplasm Thin, peripheral rim Large volume evenly distributed throughout cell To be determined
Lipid content Single large droplet occupying up to 90% of cell volume Multiple small lipid droplets To be determined
Mitochondria Few Abundant Intermediate
Endoplasmic reticulum (ER) Little, but recognizable as rough and smooth ER Present, but poorly developed To be determined
Tissue organization Small lobules of densely packed cells Lobular, gland-like To be determined
Cell content Multiple other cell types present Few other cell types present Few other cell types present
Vascularity Adequate Highly vascularised To be determined
Gene expression PPAR-gamma, aP2, Adiponectin, adipsin, perilipin UCP-1, PGC-1alpha, β-3 adreno receptor (ARB3), PRDM16, de-iodinase type II (D2) Low UCP1, but activated by cAMP stimulation
Cell markers CD34, ABCG2, ALDH EVA1, EBF3, FBXO31 CD137, TMEM26, TBX1