Hormone | Influence on BAT | Probable BAT therapeutic suggestions |
---|---|---|
Epinephrine | +ve | Selective human β3 receptor agonists |
T3 | +ve | TR β selective agonists- GC-40, KB-41 |
Testosterone | -ve | To be determined |
Estradiol | +/− (? dual effect) | Selective estrogen receptor modulators (SERM) |
Progesterone | +ve | To be determined |
DHEA | +ve | To be determined |
IGF-1 | Probably + ve | Recombinant human IGF-1 or truncated IGF-1 |
GH | +ve at higher dose | To be determined |
Insulin | Unclear | To be determined |
Cortisol | -ve | To be determined |
Prolactin | -ve | Bromocriptine, pure prolactin receptor antagonists eg., ∆1–9-G129R- hPrl (∆1–9) |
Aldosterone | -ve | Eplerenone, Spironolactone |
Endocannabinoids | -ve | Peripheral CB1 antagonists |