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Table 2 Effect of hormones on BAT and possible therapeutic options

From: Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity

Hormone Influence on BAT Probable BAT therapeutic suggestions
Epinephrine +ve Selective human β3 receptor agonists
T3 +ve TR β selective agonists- GC-40, KB-41
Testosterone -ve To be determined
Estradiol +/− (? dual effect) Selective estrogen receptor modulators (SERM)
Progesterone +ve To be determined
DHEA +ve To be determined
IGF-1 Probably + ve Recombinant human IGF-1 or truncated IGF-1
GH +ve at higher dose To be determined
Insulin Unclear To be determined
Cortisol -ve To be determined
Prolactin -ve Bromocriptine, pure prolactin receptor antagonists eg., ∆1–9-G129R- hPrl (∆1–9)
Aldosterone -ve Eplerenone, Spironolactone
Endocannabinoids -ve Peripheral CB1 antagonists
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