Figure 2

BDE-47 reduces insulin sensitivity in mice with liver-specificPtendeletion. A) Glucose tolerance of different mouse models following exposure to BDE-47 or DMSO. After an overnight fast of 16 hrs, mice were given glucose intraperitoneally (1 mg/g). Blood glucose was determined at 15, 30, 60 and 120 minutes. *, p < 0.05 Tsc1−/− vs. Pten−/− (DMSO and BDE-47 groups). B) Effects of BDE-47 on insulin sensitivity of Pten-mutant (left panel) and Tsc1-mutant (right panel) mice. *, p < 0.05, **, p < 0.01. C) Insulin sensitivity in mice of various genotypes treated with DMSO (left) and BDE-47 (right). *, p < 0.05 Tsc1−/− vs. Pten−/−.