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Table 1 Study participant characteristics and their linear associations with leukocyte telomere lengtha

From: Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus

Sample characteristic   Leukocyte telomere length tertile† Pearson’s correlation coefficient Linear regression
n Short (n = 96) Middle (n = 99) Long (n = 100) Age & gender adjusted beta (95 % CI) P-value
Leukocyte telomere length (T/S ratio)†   295 0.68 (0.05) 0.78 (0.03) 0.90 (0.08) - - -
Age (per year) †   295 65.5 (10.9) 62.0 (12.0) 57.0 (10.8) −0.30₤ −0.003 (−0.004,-0.002)₤ <0.001
Gender ‡ Male 236 84 (87.5) 78 (78.8) 74 (74.0) - REF -
  Female 59 12 (12.5) 21 (21.2) 26 (26.0) - 0.04 (0.01,0.07)€ 0.01
BMI (per kg/m2) †   290 28.1 (3.6) 29.2 (4.5) 29.1 (4.3) 0.05 0.002 (−0.002,0.005) 0.35
Waist-hip ratio (per unit) †   294 0.95 (0.06) 0.96 (0.07) 0.95 (0.07) 0.05 0.10 (−0.13, 0.34) 0.38
Waist circumference (per inch) †   294 39.2 (4.0) 39.6 (4.9) 39.6 (4.4) 0.09 0.002 (−0.001, 0.005) 0.14
Cigarette use ‡ Never 100 33 (34.4) 29 (29.3) 38 (38.0) - REF -
  Ever 195 63 (65.6) 70 (70.7) 62 (62.0) - −0.007 (−0.03, 0.02) 0.64
Cigarette pack-years (per pack-year) †   195 34.0 (25.6) 23.6 (24.8) 18.5 (19.1) −0.11 −0.0006 (−0.0011,−0.0000) 0.04
Alcoholic drinks/day (per drink) †   240 1.7 (4.9) 1.4 (7.9) 1.0 (2.5) −0.07 −0.002 (−0.004, 0.001) 0.20
NSAID use ‡ Non-current 190 58 (60.4) 64 (64.7) 68 (68.0) - REF -
  Current 105 38 (39.6) 35 (35.3) 32 (32.0) - −0.001 (−0.029, 0.027) 0.93
Statin use ‡ Non-current 265 83 (86.5) 92 (92.9) 90 (90.0) - REF  
  Current 30 13 (13.5) 7 (7.1) 10 (10.0) - −0.023 (−0.066, 0.020) 0.29
  1. Leukocyte telomere length tertile: Short < 0.735, Middle 0.735-0.846, Long ≥ 0.847
  2. † = Median (Standard deviation), ‡ = Frequency (%), ₤ = Adjusted only for gender, ¶ = Adjusted for age & gender
  3. BMI body mass index, NSAID non-steroidal anti-inflammatory drugs, CI confidence interval
  4. aThe correlation and regression values are based on leukocyte telomere length as a continuous variable
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BMC Obesity

ISSN: 2052-9538

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