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Table 2 Biomarker concentrations and their linear associations with leukocyte telomere lengthc

From: Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus

Biomarkers   Leukocyte telomere length tertileb Pearson’s correlation coefficienta Linear regression
n Short (n = 76) Middle (n = 80) Long (n = 78) Age & gender adjusted beta (95 % CI) P-value
Leptin (ng/ml) 287 7.8 (10.3) 9.5 (12.3) 10.1 (10.3) −0.01 −0.0001 (−0.002, 0.002) 0.90
Total adiponectin (mcg/ml) 226 5.2 (2.8) 5.4 (2.4) 4.4 (2.5) −0.01 −0.001 (−0.007, 0.006) 0.88
HMW adiponectin (mcg/ml) 226 1.9 (1.7) 2.0 (1.6) 1.8 (1.6) 0.01 0.001 (−0.010, 0.011) 0.90
Glucose (mg/dL) 226 91.0 (14.6) 91.5 (28.4) 93.0 (30.3) 0.04 0.0002 (−0.0004, 0.0008) 0.52
Insulin (uU/ml) 226 7.2 (5.2) 6.4 (7.7) 6.9 (5.4) −0.001 −0.0001 (−0.0024, 0.0024) 0.99
HOMA score 226 1.6 (1.3) 1.5 (3.3) 1.6 (1.7) 0.01 0.0003 (−0.006, 0.007) 0.93
C-reactive protein (mg/L) 222 2.1 (2.3) 1.8 (2.5) 2.3 (2.1) −0.04 −0.002 (−0.009, 0.005) 0.57
Interleukin-6 (pg/ml) 234 2.1 (2.7) 2.0 (2.9) 1.7 (1.6) −0.10 −0.005 (−0.011, 0.001) 0.11
sTNF-RI (ng/ml) 234 1.5 (0.5) 1.3 (0.4) 1.3 (0.5) −0.06 −0.016 (−0.050, 0.020) 0.36
sTNF-RII (ng/ml) 234 5.6 (1.6) 5.3 (1.5) 5.0 (1.1) −0.003 −0.0003 (−0.012, 0.011) 0.96
F2-isoprostanes (pg/ml) 224 54.0 (34.2) 57.5 (26.5) 54.0 (38.3) −0.04 −0.0002 (−0.0006, 0.0003) 0.53
  1. Leukocyte telomere length tertile: Short < 0.735, Middle 0.735-0.846, Long ≥ 0.847
  2. sTNF-RI & RII soluble tumor necrosis factor receptor I & II, HMW high molecular weight, HOMA score homeostatic model assessment score
  3. aAdjusted for age & gender
  4. bMedian (standard deviation)
  5. cThe correlation and regression values are based on leukocyte telomere length as a continuous variable