Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus

Sheetal Hardikar; Xiaoling Song; Rosa Ana Risques; Thomas J. Montine; Catherine Duggan; Patricia L. Blount; Brian J. Reid; Garnet L. Anderson; Mario Kratz; Emily White; Thomas L. Vaughan

doi:10.1186/s40608-015-0063-3

BMC Obesity

Table 3 Odds ratios (OR) for short LTL^a by subject characteristics and markers of inflammation

From: Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus

Characteristic	N	Unadjusted OR (95 % CI)	Age & gender adjusted OR (95 % CI)	Age, gender, smoking & obesity^€ adjusted OR (95 % CI)
Age (per year)	295	1.05 (1.03,1.07)	1.05 (1.03,1.08) ^₤	1.04 (1.02,1.07) ^₤
Gender (Females vs. males)	295	0.46 (0.23,0.92)	0.43 (0.21,0.87) ^€	0.37 (0.18,0.78) ^€
BMI (per kg/m²)	290	0.91 (0.85,0.97)	0.93 (0.87,1.00)	0.96 (0.86,1.07)
Waist circumference (per inch)	294	0.96(0.91,1.02)	0.94(0.88,1.00)	0.94 (0.88,1.00)
Waist-hip ratio (per unit)	294	1.11(0.77,1.60)	0.72(0.45,1.16)	0.92 (0.49,1.74)
Cigarette use (Ever vs. never)	295	1.01 (1.00,1.03)	1.01 (0.99,1.03)	0.99 (0.96,1.03)
Pack-years continuous (per pack-year)	295	1.01 (1.00,1.02)	1.01 (1.00,1.02)	1.01 (1.00,1.02)
Pack-years Tertiles				-
Non-smokers		REF	REF	REF
T1 (0.05-)		0.58 (0.28,1.20)	0.64 (0.30,1.35)	0.64 (0.30,1.37)
T2 (14-)		0.91 (0.47,1.76)	0.79 (0.40,1.57)	0.84 (0.42,1.70)
T3 (36-)		1.58 (0.83,3.01)	1.30 (0.66,2.56)	1.40 (0.70,2.77)
p-trend^b		0.04**	0.27	0.20
Leptin (ng/ml)	226	0.98 (0.95,1.01)	1.00 (0.97,1.04)	1.05 (1.01,1.12)
Total Adiponectin (mcg/ml)	226	1.08 (0.97,1.20)	1.00 (0.88,1.15)	0.98 (0.85,1.12)
HMW Adiponectin (mcg/ml)	226	1.10 (0.92,1.30)	0.98 (0.79,1.21)	0.92 (0.74,1.15)
Glucose (mg/dL)	226	0.99 (0.98,1.01)	0.99 (0.97,1.01)	0.99 (0.97,1.01)
Insulin (uU/ml)	226	1.00 (0.95,1.04)	1.00 (0.95,1.05)	1.02 (0.97,1.07)
HOMA score	226	0.95 (0.82,1.09)	0.95 (0.81,1.12)	1.01 (0.86,1.18)
CRP continuous (mg/L)	222	0.98 (0.87,1.11)	0.95 (0.82,1.09)	0.98 (0.84,1.13)
CRP Tertiles
T1 (0.1-)		REF	REF	REF
T2 (1.1-)		1.36 (0.67,2.74)	1.40 (0.66,2.96)	1.69 (0.78,3.68)
T3 (2.9-)		0.91 (0.45,1.85)	0.81 (0.37,1.78)	1.04 (0.45,2.40)
p-trend^b		0.74	0.44	0.74
IL-6 continuous (pg/ml)	234	1.06 (0.95,1.17)	1.02 (0.90,1.15)	1.04 (0.92,1.18)
IL-6 Tertiles
T1 (0.4-)		REF	REF	REF
T2 (1.5-)		1.45 (0.74,2.86)	1.21 (0.58,2.50)	1.25 (0.59,2.62)
T3 (2.6-)		1.25 (0.63-2.47)	1.07 (0.50,2.31)	1.22 (0.55,2.71)
p-trend^b		0.32	0.77	0.51
sTNF-RI continuous (ng/ml)	234	3.30 (1.75,6.23)	2.02 (1.02,3.99)	2.30 (1.11,4.78)
sTNF-RI Tertiles
T1 (0.3-)		REF	REF	REF
T2 (1.2-)		1.14 (0.56,2.33)	0.90 (0.42,1.91)	1.00 (0.46,2.15)
T3 (1.5-)		3.25 (1.64,6.43)	1.81 (0.85,3.84)	2.19 (1.00,4.85)
p-trend^b		<0.001**	0.04**	0.02 **
sTNF-RII continuous (ng/ml)	234	1.30 (1.07,1.58)	1.08 (0.86,1.35)	1.06 (0.84,1.33)
sTNF-RII Tertiles
T1 (2.1-)		REF	REF	REF
T2 (4.9-)		0.90 (0.44,1.82)	0.64 (0.30,1.37)	0.68 (0.32,1.47)
T3 (6.0-)		2.52 (1.29,4.90)	1.42 (0.66,3.04)	1.45 (0.67,3.15)
p-trend^b		0.01**	0.50	0.62
F2-isoprostanes continuous (pg/ml)	224	1.00 (0.99,1.01)	1.00 (1.00,1.01)	1.01 (1.00,1.02)
F2-isoprostane Tertiles
T1 (14-)		REF	REF	REF
T2 (48-)		0.62 (0.31,1.25)	0.67 (0.32,1.41)	0.72 (0.34,1.52)
T3 (67-)		0.93 (0.48,1.83)	1.28 (0.60,2.71)	1.55 (0.71,3.39)
p-trend^b		0.88	0.31	0.18

LTL leukocyte telomere length, BMI body mass index, CRP c-reactive protein, IL-6 interleukin-6, sTNF-RI & RII Soluble tumor necrosis factor receptor I & II, CI confidence interval
£ - Adjusted for cigarette pack-years smoked at baseline, € - Adjusted for waist circumference at baseline, ₤ = Adjusted only for gender, € = Adjusted only for age
** p-value significant at 0.05 level
^aShort LTL defined as lowest tertile (T/S ratio < 0.735)
^bTest for trend based on the likelihood-ratio test associated with addition of the variable under consideration in its continuous form

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