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Table 3 Odds ratios (OR) for short LTLa by subject characteristics and markers of inflammation

From: Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus

Characteristic N Unadjusted OR (95 % CI) Age & gender adjusted OR (95 % CI) Age, gender, smoking & obesity€ adjusted OR (95 % CI)
Age (per year) 295 1.05 (1.03,1.07) 1.05 (1.03,1.08) ₤ 1.04 (1.02,1.07) ₤
Gender (Females vs. males) 295 0.46 (0.23,0.92) 0.43 (0.21,0.87) € 0.37 (0.18,0.78) €
BMI (per kg/m2) 290 0.91 (0.85,0.97) 0.93 (0.87,1.00) 0.96 (0.86,1.07)
Waist circumference (per inch) 294 0.96(0.91,1.02) 0.94(0.88,1.00) 0.94 (0.88,1.00)
Waist-hip ratio (per unit) 294 1.11(0.77,1.60) 0.72(0.45,1.16) 0.92 (0.49,1.74)
Cigarette use (Ever vs. never) 295 1.01 (1.00,1.03) 1.01 (0.99,1.03) 0.99 (0.96,1.03)
Pack-years continuous (per pack-year) 295 1.01 (1.00,1.02) 1.01 (1.00,1.02) 1.01 (1.00,1.02)
Pack-years Tertiles     -
Non-smokers   REF REF REF
T1 (0.05-)   0.58 (0.28,1.20) 0.64 (0.30,1.35) 0.64 (0.30,1.37)
T2 (14-)   0.91 (0.47,1.76) 0.79 (0.40,1.57) 0.84 (0.42,1.70)
T3 (36-)   1.58 (0.83,3.01) 1.30 (0.66,2.56) 1.40 (0.70,2.77)
p-trendb   0.04** 0.27 0.20
Leptin (ng/ml) 226 0.98 (0.95,1.01) 1.00 (0.97,1.04) 1.05 (1.01,1.12)
Total Adiponectin (mcg/ml) 226 1.08 (0.97,1.20) 1.00 (0.88,1.15) 0.98 (0.85,1.12)
HMW Adiponectin (mcg/ml) 226 1.10 (0.92,1.30) 0.98 (0.79,1.21) 0.92 (0.74,1.15)
Glucose (mg/dL) 226 0.99 (0.98,1.01) 0.99 (0.97,1.01) 0.99 (0.97,1.01)
Insulin (uU/ml) 226 1.00 (0.95,1.04) 1.00 (0.95,1.05) 1.02 (0.97,1.07)
HOMA score 226 0.95 (0.82,1.09) 0.95 (0.81,1.12) 1.01 (0.86,1.18)
CRP continuous (mg/L) 222 0.98 (0.87,1.11) 0.95 (0.82,1.09) 0.98 (0.84,1.13)
CRP Tertiles     
T1 (0.1-)   REF REF REF
T2 (1.1-)   1.36 (0.67,2.74) 1.40 (0.66,2.96) 1.69 (0.78,3.68)
T3 (2.9-)   0.91 (0.45,1.85) 0.81 (0.37,1.78) 1.04 (0.45,2.40)
p-trendb   0.74 0.44 0.74
IL-6 continuous (pg/ml) 234 1.06 (0.95,1.17) 1.02 (0.90,1.15) 1.04 (0.92,1.18)
IL-6 Tertiles     
T1 (0.4-)   REF REF REF
T2 (1.5-)   1.45 (0.74,2.86) 1.21 (0.58,2.50) 1.25 (0.59,2.62)
T3 (2.6-)   1.25 (0.63-2.47) 1.07 (0.50,2.31) 1.22 (0.55,2.71)
p-trendb   0.32 0.77 0.51
sTNF-RI continuous (ng/ml) 234 3.30 (1.75,6.23) 2.02 (1.02,3.99) 2.30 (1.11,4.78)
sTNF-RI Tertiles     
T1 (0.3-)   REF REF REF
T2 (1.2-)   1.14 (0.56,2.33) 0.90 (0.42,1.91) 1.00 (0.46,2.15)
T3 (1.5-)   3.25 (1.64,6.43) 1.81 (0.85,3.84) 2.19 (1.00,4.85)
p-trendb   <0.001** 0.04** 0.02 **
sTNF-RII continuous (ng/ml) 234 1.30 (1.07,1.58) 1.08 (0.86,1.35) 1.06 (0.84,1.33)
sTNF-RII Tertiles     
T1 (2.1-)   REF REF REF
T2 (4.9-)   0.90 (0.44,1.82) 0.64 (0.30,1.37) 0.68 (0.32,1.47)
T3 (6.0-)   2.52 (1.29,4.90) 1.42 (0.66,3.04) 1.45 (0.67,3.15)
p-trendb   0.01** 0.50 0.62
F2-isoprostanes continuous (pg/ml) 224 1.00 (0.99,1.01) 1.00 (1.00,1.01) 1.01 (1.00,1.02)
F2-isoprostane Tertiles     
T1 (14-)   REF REF REF
T2 (48-)   0.62 (0.31,1.25) 0.67 (0.32,1.41) 0.72 (0.34,1.52)
T3 (67-)   0.93 (0.48,1.83) 1.28 (0.60,2.71) 1.55 (0.71,3.39)
p-trendb   0.88 0.31 0.18
  1. LTL leukocyte telomere length, BMI body mass index, CRP c-reactive protein, IL-6 interleukin-6, sTNF-RI & RII Soluble tumor necrosis factor receptor I & II, CI confidence interval
  2. £ - Adjusted for cigarette pack-years smoked at baseline, € - Adjusted for waist circumference at baseline, ₤ = Adjusted only for gender, € = Adjusted only for age
  3. ** p-value significant at 0.05 level
  4. aShort LTL defined as lowest tertile (T/S ratio < 0.735)
  5. bTest for trend based on the likelihood-ratio test associated with addition of the variable under consideration in its continuous form
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