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Table 2 Pharmacokinetic parameters (non-compartmental analysis) of [9-14C]-oleic acid and/or its metabolites in plasma and blood of Göttingen minipigs after a single oral dose of [9-14C]-Oleic to untreated minipigs (group A) and minipigs that were pre-treated with 2 tablets of 500 mg formoline L112 (group B)
| Group | A | B | %a | A | B | %a |
|---|---|---|---|---|---|---|
| Plasma | Blood | |||||
| Pharmacokinetic parameters | ||||||
| Tmax (h) | 4 ± 3 | 16 ± 9* | - | 4 ± 3 | 14 ± 11 | - |
| Cmax (μg/g) | 14.1 ± 3.6 | 3.3 ± 1.2** | 23.4 | 8.5 ± 2.2 | 2.1 ± 0.8** | 24.7 |
| AUC(0-12h) (h* μg/g) | 65.6 ± 6.0 | 21.6 ± 14.0** | 32.9 | 40.0 ± 4.8 | 13.3 ± 9.1** | 33.3 |
| AUC(0-24h) (h* μg/g) | 98.4 ± 17.2 | 49.9 ± 20.8** | 50.7 | 61.7 ± 13.1 | 29.8 ± 12.9** | 48.3 |
| AUC(0-48h) (h* μg/g) | 136 ± 28 | 91.0 ± 23.2* | 66.9 | 88.3 ± 19.0 | 56.9 ± 13.1* | 64.4 |
| AUC(0-60h) (h* μg/g) | 148 ± 31 | 105 ± 25* | 70.9 | 97.2 ± 20.6 | 67.3 ± 13.8* | 69.2 |
| AUC(0-72h) (h* μg/g) | 157 ± 32 | 116 ± 26 | 73.9 | 105 ± 22 | 76.4 ± 14.2* | 72.8 |
| AUCall(0-144h) (h* μg/g) | 190 ± 38 | 158 ± 32 | 83.2 | 139 ± 25 | 118 ± 16 | 84.9 |
| Vz (g/kg) | 7008 ± 2962 | 5629 ± 1946 | - | 8860 ± 1848 | 9515 ± 1647 | - |
| Cl (g/h/kg) | 40.7 ± 5.5 | 49.8 ± 8.3 | - | 48.4 ± 7.9 | 47.6 ± 7.3 | - |
| MRTlast (h) | 35.9 ± 1.8 | 50.2 ± 5.1** | - | 43.6 ± 3.1 | 58.4 ± 5.7** | - |
