Adjusted for center only | Adjusted for all significant predictors | |||||
---|---|---|---|---|---|---|
Patients without IBS | Patients with IBS | Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value | |
Gender (%male) | 84 (28%) | 6 (11%) | 0.35 (0.14–0.87) | 0.02 | 0.57 (0.18–1.82) | 0.34 |
Age (years) | 44 (21–61) | 41 (23–61) | 0.97 (0.94–1.00) | 0.07 | ||
Body mass index (kg/m2) | 42 (33–62) | 42 (36–53) | 0.98 (0.92–1.06) | 0.64 | ||
Ethnicity (% Caucasian) | 281/296 (95%) | 53/54 (98%) | 1.34 (0.17–10.82) | 0.51 | ||
Smoking | 68/291 (23%) | 12/52 (23%) | 1.24 (0.60–2.59) | 0.56 | ||
Diabetes mellitus | 72/296 (24%) | 7/54 (13%) | 0.51 (0.22–1.20) | 0.12 | ||
Hypothyroidism | 29/296 (10%) | 7/53 (13%) | 1.27 (0.51–3.16) | 0.61 | ||
Fibromyalgia | 33/295 (11%) | 12/54 (22%) | 1.86 (0.86–4.00) | 0.12 | ||
Self-reported psychiatric disorder | 47/296 (16%) | 18/54 (33%) | 2.61 (1.33–5.13) | 0.005 | 2.39 (1.12–5.08) | 0.02 |
Hemoglobin (g/dl) | 14.3 (1.1) | 14.0 (1.1) | 0.65 (0.49–0.88) | 0.004 | 0.68 (0.45–1.02) | 0.07 |
White-cell count (×109/l) | 7.5 (2.8–16.1) | 7.3 (2.4–11.3) | 0.85 (0.72–1.00) | 0.05 | ||
Platelet count (×109/l) | 275 (112–519) | 294 (131–939) | 1.00 (1.00–1.01) | 0.14 | ||
C-reactive protein (mg/l) | 6 (0–50) | 5 (1–23) | 0.97 (0.92–1.03) | 0.33 | ||
Cholesterol (mmol/l) | 4.9 (1.0) | 5.4 (0.8) | 1.73 (1.23–2.43) | 0.002 | ||
High-density lipoprotein (mmol/l) | 1.1 (0.4–2.2) | 1.1 (0.7–2.0) | 1.02 (0.39–2.67) | 0.97 | ||
Low-density lipoprotein (mmol/l) | 3.1 (0.9) | 3.6 (0.7) | 1.85 (1.27–2.70) | 0.001 | 2.10 (1.34–3.29) | 0.001 |
Thyroid stimulating hormone (mIE/l) | 1.5 (0.0–7.9) | 1.7 (0.2–14.6) | 0.02 | 0.08 | ||
Free T4 (pmol/l) | 15 (10–28) | 15 (11–23) | 0.97 (0.85–1.10) | 0.17 | ||
Vitamin B1 (nmol/l) | 155 (62–239) | 142 (91–246) | 0.98 (0.97–1.00) | 0.008 | 0.99 (0.98–1.01) | 0.21 |
Vitamin B6 (nmol/l) | 26 (5–231) | 26 (6–113) | 0.99 (0.98–1.01) | 0.36 | ||
Vitamin B12 (pmol/l) | 346 (158–1480) | 342 (173–712) | 1.00 (1.00–1.00) | 0.52 | ||
Folic acid (nmol/l) | 18 (6–46) | 16 (7–46) | 0.98 (0.94–1.02) | 0.28 | ||
Use of statins | 52/295 (18%) | 2/54 (4%) | 0.18 (0.04–0.78) | 0.02 | 0.31 (0.07–1.47) | 0.14 |
Use of thyroid substitution therapy | 26/296 (9%) | 6/54 (11%) | 1.30 (0.49–3.46) | 0.60 | ||
Center | 5.22 (2.48–10.99) | <0.001 |