Skip to main content

Table 2 Primary analysis 1 – Estimated mean change from pre- to post-RYGB in each biochemical liver function test, non-invasive ICG clearance test, and histological measures

From: Reversal of fibrosis in patients with nonalcoholic steatohepatosis after gastric bypass surgery

      Mean Difference
Variable   N Pre-RYG Post-RYGB (99.8% CI)† P-value†
AST, U/L 25 29.9 ± 9.3 23.6 ± 7.9 −6.32 (−15.6, 2.94)   0.03
ALT, U/L 25 31 [26, 38] 20 [17, 34] −7.56 (−22.0, 6.83)   0.08
ALK, U/L 25 78.2 ± 19.1 84.0 ± 14.9 5.84 (−7.55, 19.2)   0.14
Total bilirubin, mg/dL 25 0.5 [0.4, 0.4 [0.4, 0.01 (−0.15, 0.17)   0.79
Albumin, g/dL 25 4.4 ± 0.3 4.2 ± 0.3 −0.20 (−0.38, −0.02)   <0.001
PT, second 25 11.3 ± 0.6 11.1 ± 0.5 −0.23 (−0.68, 0.23)   0.10
PTT, second 6 29.8 ± 1.6 28.0 ± 0.3 −1.72 (−8.68, 5.25)   0.21
ICG K value 19 0.21 ± 0.04 0.22 ± 0.06 0.01 (−0.04, 0.06)   0.63
NAS steatosis, No. (%) 15     0.002
  < 5%   2 (13) 11 (73)    
 5–33%   6 (40) 3 (20)    
 34–66%   5 (33) 1 (7)    
  > 66%   2 (13) 0 (0)    
NAS lobular inflammation, No. (%) 15     0.04
 No foci   3 (20) 10 (67)    
  < 2 foci / 200×   8 (53) 4 (27)    
 2–4 foci / 200×   3 (20) 1 (7    
  > 4 foci / 200×   1 (7) 0 (0)    
NAS Hepatocyte Balloon, No. (%) 15      0.001
 Absent 3 (20)   12 (80)    
 Few Balloon Cells 10 (67)   3 (20)    
 Many Cells 2 (13)   0 (0)    
Fibrosis, No. (%) 15     0.005
 None   0 (0) 6 (40)    
 Perisinusoidal or periportal   0 (0) 0 (0)    
 1A - Mild, zone 3, perisinusoidal   5 (33) 0 (0)    
 1B - Moderate, zone 3, perisinusoidal   1 (7) 1 (7)    
 1C - Portal/periportal   1 (7) 5 (33)    
 2 - Perisinusoidal and portal/periportal   5 (33) 2 (13)    
 3 - Bridging fibrosis   3 (20) 1 (7)    
 4 - Cirrhosis   0 (0) 0 (0)    
  1. AST Aspartate transaminase, ALT Alanine transaminase, ALK alkaline phosphatase, ICG Indocyanine green, NAS Nonalcoholic steatohepatitis, PT Prothrombin time, PTT Partial Thromboplastin Time
  2. P-value for testing the null hypothesis that difference is zero using the paired t-test or Wilcoxon signed rank test, as appropriate. The significance criterion was P < 0.002 (i.e., 0.025 / 12; Bonferroni correction)