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Table 2 Studies on the insulin resistance risk associated with SSB consumption

From: The negative impact of sugar-sweetened beverages on children’s health: an update of the literature

Author, Year

Setting

Sample Size

Sample Age

Method of Diet Assessment

SSB Unit of Analysis

Primary Outcome

Direction of Association

Findings

Cross-Sectional Studies

Bremer, 2009

Nationally representative sample of U.S. adolescents, NHANES, 1994-2004

6967

12-19 years

Single 24-hour dietary recall interview

Increment of a serving/day (serving = 250g)

Change in HOMA-IR

Positive

β = 0.05 [SE= 0.02]*

Bremer, 2010

Nationally representative sample of U.S. adolescents, NHANES, 1999-2004

6967

12-19 years

Single 24-hour dietary recall interview

Increment of a serving/day (serving = 250g)

Change in HOMA-IR

Mixed

Non-Hispanic White:

β= 0.06 [SE=0.02]*

Non-Hispanic Black:

β=0.12 [SE=0.05]*

Mexican Americans:

β=0.04 [SE=0.04]

Kondaki, 2012

Adolescents in large multicenter European study

546

12-17 years

Mini FFQ from Health Behavior in School-Aged Children study

≥1 time/day vs. <1 time/week

5-6 times/week vs. <1 time/week

2-4 times/week vs. <1 time/week, (serving = not reported)

Change in HOMA-IR

Positive

≥1 time/day vs. ≤ 1 time/week

β = 0.19 [95%CI: 0.003, 0.38]*

5-6 times/week vs. ≤1 time/week

β = 0.28 [95%CI: 0.07, 0.49]*

2-4 times/week vs. ≤ 1 time/week

β =0.080 [95%CI:

-0.084, 0.245]

Santiago-Torres, 2016

Hispanic children attending inner-city school in Milwaukee

187

10-14 years

Block for Kid’s FFQ with Hispanic foods

SSB consumption, (serving = not reported)

Change in HOMA-IR

Positive

β =0.104*

No measure of variation reported

Wang, 2012

Caucasian children recruited from primary schools in Canada

632

8-10 years

Three 24-hour dietary recalls

Increment of a serving/day (serving = 100ml)

Change in HOMA-IR

Mixed

Null overall

Positive in one sub-group

Null in one sub-group

Among all children:

β =0.024

> 85th BMI percentile

β = 0.097*

<85th BMI percentile

β =-0.027

No measure of variation reported

Longitudinal Studies

Wang, 2014

Caucasian Canadian children with at least one obese parent

564

8-10 years

Three 24-hour dietary recalls

Increment of 10g/day of added sugar from liquid sources

HOMA-IR

Positive

Among all children:

0.091 [95%CI: 0.034, 0.149] *

Overweight/ obese:

0.121 [95%CI: 0.013, 0.247] *

Normal weight:

0.046 [95%CI:

-0.003, 0.096]

  1. Note: *indicates statistical significance (p<0.05) as reported by each study