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Table 3 Adjusted associations between log-transformed metabolic risk factors, insulin resistance [HOMA-IR (units)] and serum lipids (TG, TC, HDL-C and LDL-C (mmol/l)), and hsCRP (μg/ml) in black and white South African women

From: The association between high-sensitivity C-reactive protein and metabolic risk factors in black and white South African women: a cross-sectional study

Variables Model 1 Model 2 Model 3
ln(HOMA-IR) β [95% CI] β [95% CI] β [95% CI]
hsCRP 0.09 [0.05; 0.13]** 0.10 [0.06; 0.14]** 0.03 [−0.01; 0.07]
Age −0.01 [− 0.02; 0.00] − 0.01 [− 0.02; 0.00] − 0.02 [− 0.03; − 0.01]**
Race/ethnicity 0.26 [0.03; 0.48]* 0.00 [− 0.27; 0.27] − 0.00 [− 0.23; 0.23]
hsCRPxrace/ethnicity − 0.02 [− 0.07; 0.04] −0.04 [− 0.09; 0.02] −0.02 [− 0.07; 0.02]
Adjusted-R 2 0.11** 0.15** 0.38**
ln(TG) β [95% CI] β [95% CI] β [95% CI]
hsCRP 0.07 [0.05; 0.10]** 0.06 [0.04; 0.09]** 0.04 [0.02; 0.07]**
Age 0.01 [0.00; 0.01]* 0.01 [0.00; 0.02]* 0.01 [−0.00; −0.00]
Race/ethnicity −0.04 [− 0.18; 0.10] −0.14 [− 0.30; 0.03] −0.14 [− 0.30; 0.02]
hsCRPxrace/ethnicity − 0.05 [− 0.09; − 0.02]* −0.05 [− 0.08; − 0.01]* −0.04 [− 0.08; − 0.01]*
Adjusted-R 2 0.18** 0.20** 0.26**
ln(TC) β [95% CI] β [95% CI] β [95% CI]
hsCRP 0.02 [0.01; 0.03]* 0.02 [0.00; 0.03]* 0.01 [−0.00; 0.02]
Age 0.00 [0.00; 0.01]* 0.01 [0.00; 0.01]** 0.01 [0.00; 0.01]**
Race/ethnicity −0.05 [− 0.11; 0.02] −0.04 [− 0.12; 0.03] −0.04 [− 0.12; 0.03]
hsCRPxrace/ethnicity − 0.04 [− 0.06; − 0.03]** −0.03 [− 0.05; − 0.02]** −0.03 [− 0.05; − 0.01]**
Adjusted-R 2 0.26** 0.29** 0.30**
ln(HDL-C) β [95% CI] β [95% CI] β [95% CI]
hsCRP −0.01 [− 0.03; − 0.01]* −0.02 [− 0.03; − 0.00]* −0.00 [− 0.02; 0.01]
Age − 0.00 [− 0.01; 0.00] −0.00 [− 0.00; 0.00] 0.00 [− 0.00; 0.01]
Race/ethnicity −0.16 [− 0.25; − 0.07]** −0.01 [− 0.12; 0.09] −0.03 [− 0.13; 0.08]
hsCRPxrace/ethnicity − 0.03 [− 0.05; − 0.01]* −0.02 [− 0.04; 0.01] −0.02 [− 0.04; 0.00]
Adjusted-R 2 0.22** 0.34** 0.39**
ln(LDL-C) β [95% CI] β [95% CI] β [95% CI]
hsCRP 0.03 [0.01; 0.05]* 0.02 [−0.00; 0.04]* 0.01 [−0.02; 0.03]
Age 0.01 [−0.00; 0.01] 0.01 [0.00; 0.12]* 0.01 [−0.00; 0.01]
Race/ethnicity −0.02 [− 0.14; 0.09] −0.14 [− 0.29; 0.01] −0.13 [− 0.27; 0.02]
hsCRPxrace/ethnicity − 0.04 [− 0.07; − 0.01]* −0.03 [− 0.06; 0.00] −0.03 [− 0.06; 0.00]
Adjusted-R 2 0.08** 0.15** 0.19**
  1. Data represents β-coefficients [95% confidence interval] and adjusted-R2. Model 1: hsCRP + age + race/ethnicity + (hsCRP x race/ethnicity interaction); Model 2: (Model 1) + SES + lifestyle factors; Model 3: (Model 2) + WC. hsCRP, C-reactive protein; interaction term, interaction between hsCRP and race/ethnicity; ln(HOMA-IR), ln(TG), natural log of triglycerides; natural log of homeostatic model assessment; ln(TC), natural log of total cholesterol; ln(HDL-C), natural log of high-density lipoprotein cholesterol; ln(LDL-C), natural log of low-density lipoprotein cholesterol. *p < 0.05 and **p < 0.001