TY - JOUR AU - Alkandari, Abdullah AU - Ashrafian, Hutan AU - Sathyapalan, Thozhukat AU - Sedman, Peter AU - Darzi, Ara AU - Holmes, Elaine AU - Athanasiou, Thanos AU - Atkin, Stephen L. AU - Gooderham, Nigel J. PY - 2018 DA - 2018/05/31 TI - Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans JO - BMC Obesity SP - 20 VL - 5 IS - 1 AB - The global pandemic of obesity and the metabolic syndrome are leading causes of mortality and morbidity. Bariatric surgery leads to sustained weight loss and improves obesity-associated morbidity including remission of type 2 diabetes. MicroRNAs are small, endogenous RNAs that regulate gene expression post-transcriptionally, controlling most of the human transcriptome and contributing to the regulation of systemic metabolism. This preliminary, longitudinal, repeat sampling study, in which subjects acted as their own control, aimed to assess the temporal effect of bariatric surgery on circulating microRNA expression profiles. SN - 2052-9538 UR - https://doi.org/10.1186/s40608-018-0199-z DO - 10.1186/s40608-018-0199-z ID - Alkandari2018 ER -