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Table 4 Adjusted Parameter Estimatesa between rs7903146-T and Body Mass Indicesb at the Hispanic Community Health Study/Study of Latinos Baseline Examination Representing 9031 Individuals (21–76 Years of Age), and at Several Ages Across the Lifecourse

From: Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos

  Sample Sizec Estimated Change in kg/m2 (95% CI) per T2D risk allele P-value
Measured BMI at Examination n = 9012 −0.37 (− 0.69, − 0.06) 0.019
Self-reported BMI at Examination n = 8921 −0.38 (− 0.69, − 0.08) 0.015
Self-reported BMI at 21 Years n = 8759 −0.20 (− 0.45, 0.04) 0.109
Self-reported BMI at 45 Years n = 5605 − 0.18 (− 0.43, 0.06) 0.134
Self-reported BMI at 65 Years n = 729 0.01 (− 0.82, 0.84) 0.980
  1. Abbreviations: BMI Body mass index, T2D Type 2 diabetes, 95% CI 95% confidence interval
  2. aCorresponding to the additive number of T2D risk alleles at TCF7L2 (rs7903146-T) and then adjusted for age, sex, education level, genetic ancestry group and ancestry proportions
  3. bBody mass index (BMI) was based on self-reported or measured weight in kg, and divided by squared measured height at examination in meters (kg/m2)
  4. cUnweighted sample size differences were a result of individuals missing certain weight measurements. For example, only individuals that were had reached 21, 45 or 65 years of age were asked to provide their weight for that particular age