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Table 2 Predictors of Dysbiosis Index and Alternative Dysbiosis Index (linear regression analyses)

From: Separating “good” from “bad” faecal dysbiosis – evidence from two cross-sectional studies

Independent predictors Dependent: DI (all variables) Dependent: DI (stepwise forward) Dependent: ADI (all variables) Dependent: ADI (stepwise forward)
B (95% CI) p-value pc B (95%CI) p-value pc B (95% CI) p-value pc B (95%CI) p-value pc
Gender (female/male) 1.01
(0.17; 1.85)
0.19 0.275     −0.96
(−2.61; 0.70)
0.25 −0.137    
Age (years) −0.01
(−0.05; 0.02)
0.46 −0.088     0.05
(−0.02; 0.13)
0.15 0.172 0.07 (0.01; 0.13) 0.033 0.241
BMI (kg/m2) −0.00
(−0.08; 0.08)
0.95 −0.007     −0.07
(−0.23; 0.09)
0.38 −0.105    
Smoking (never/ previously /daily) 0.36
(−0.08; 0.80)
0.10 0.193     −0.67
(−1.53; 0.19)
0.12 −0.183    
Coffee (cups/day) −0.02
(−0.16 to 0.13)
0.79 −0.032     0.02
(−0.26; 0.31)
0.87 0.020    
IBSSS (86) 0.00
(−0.002; 0.004)
0.47 0.086     −0.006
(−0.01; 0.00)
0.039 −0.244 −0.01
(−0.01; −0.00)
0.022 −0.258
Metformin 0.99
(0.22; 1.75)
0.012 0.295 1.11
(0.42; 1.80)
0.002 0.339 2.53
(1.04; 4.03)
0.001 0.374 2.32
(0.93; 3.71)
0.001 0.354
Water (unit a) 0.00
(−0.02; 0.02)
0.98 −0.002     −0.01
(−0.04; 0.03)
0.76 −0.037    
Carb. bev. w/ sugar (unit a) 0.20
(−0,05; 0.45)
0.12 0.186     0.13
(−0.37; 0.63)
0.60 0.062    
Total NNS (unit a) 0.035
(−0.00; 0.07)
0.054 0.228 0.04
(0.01; 0.07)
0.005 0.311 −0.08
(−0.15; −0.01)
0.024 −0.266 −0.10
(−0.16; −0.04)
0.001 −0.362
Starch (g/day) −0.00
(−0.01; 0.00)
0.36 −0.109     −0.00
(−0.02; 0.01)
0.53 −0.076    
  1. DI Dysbiosis Index, ADI Alternative Dysbiosis Index, IBSSS Irritable Bowel Severity Scoring System, NNS Non-Nutritive Sweeteners, pc partial correlation, Carb. bev: Carbonated beverages. aOne unit is 100 ml beverages with NNS or 2 tablets NNS for coffee/tea
  2. Gender and BMI and all variables significantly associated with either DI of ADI in the univariate analyses (age, smoking habits, coffee, IBSSS, Metformin, total NNS, starch) were included as predictors of DI and ADI in the regression analyses. The reasons for exclusion of diabetes and some nutrients are explained in the text. All the variables were included in the first step, and then stepwise forward regression analyses were performed
  3. Italicized p-values are statistically significant