|
Variable
|
Treatment group
|
Estimated treatment effect (90 % C.I.)a
|
|---|
|
LLLT (N = 15) ± SD
|
Lorcaserin (N = 14) ± SD
|
Combination (N = 15b) ± SD
|
Combination vs. LLLT only
|
Combination vs. Lorcaserin only
|
|---|
|
Weight, kg
|
|
Baseline
|
96.0 ± 15.3
|
94.4 ± 16.2
|
90.3 ± 14.0
| | |
|
Week 12
|
95.0 ± 14.2
|
90.7 ± 17.4
|
86.7 ± 14.2
|
−2.6 (-5.0, -0.3)
|
+0.1 (-2.3, +2.5)
|
|
Delta
|
−1.0 ± 4.4
|
−3.7 ± 3.3c
|
−3.5 ± 3.6c
|
P = .070
|
P = .950
|
|
Weight loss of >5 %, n (%)
|
2 (13)
|
8 (57)
|
5 (33)
| | |
|
Body Mass Index, kg/m2
|
|
Baseline
|
33.5 ± 3.9
|
33.6 ± 5.1
|
33.4 ± 4.2
| | |
|
Week 12
|
33.1 ± 3.5
|
32.3 ± 5.7
|
32.1 ± 4.3
|
−1.0 (-1.8, -0.1)
|
+0.0 (-0.8, +0.9)
|
|
Delta
|
−0.4 ± 1.5
|
−1.3 ± 1.2c
|
−1.3 ± 1.3c
|
P = .063
|
P = .973
|
|
Waist Circumference, cm
|
|
Baseline
|
105.3 ± 11.6
|
108.0 ± 15.7
|
100.9 ± 10.0
| | |
|
Week 12
|
103.0 ± 11.3
|
102.0 ± 16.3
|
96.9 ± 12.4
|
−1.8 (-5.4, +1.7)
|
+1.7 (-1.9, +5.4)
|
|
Delta
|
−2.3 ± 4.1d
|
−6.0 ± 7.3c
|
−4.0 ± 5.5d
|
P = .398
|
P = .436
|
|
Hip Circumference, cm
|
|
Baseline
|
119.1 ± 8.8
|
120.7 ± 12.1
|
119.0 ± 8.8
| | |
|
Week 12
|
118.1 ± 8.3
|
116.2 ± 12.0
|
116.0 ± 9.3
|
−2.0 (-3.6, -0.3)
|
+1.5 (-0.2, +3.2)
|
|
Delta
|
−1.0 ± 3.1
|
−4.5 ± 2.1e
|
−3.0 ± 3.0c
|
P = .059
|
P = .159
|
|
Waist-to-Hip ratio
|
|
Baseline
|
0.885 ± 0.086
|
0.892 ± 0.072
|
0.850 ± 0.063
| | |
|
Week 12
|
0.874 ± 0.086
|
0.874 ± 0.087
|
0.834 ± 0.068
|
−0.007 (-0.032, +0.018)
|
−0.001 (-0.027, +0.025)
|
|
Delta
|
−0.011 ± 0.035
|
−0.017 ± 0.053
|
−0.016 ± 0.032
|
P = .657
|
P = .961
|
-
CI Confidence Interval, SD Standard Deviation
-
aEstimated treatment effect from analysis of covariance (ANCOVA) with the baseline value of the given variable included as a covariate
-
bThere were 2 subjects in the combination group who discontinued prior to week 12 (one after week 2 and one after week 6). For these 2 subjects the last value of each variable was carried forward to week 12
-
c
p < 0.01 for paired t-test comparing week 12 versus baseline
-
d
p < 0.05 for paired t-test comparing week 12 versus baseline
-
e
p < 0.001 for paired t-test comparing week 12 versus baseline
