Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond). 2008;32:1431–7.
Article
CAS
Google Scholar
International Diabetes Federation. IDF Diabetes Atlas. 6th ed. Brussels; 2013. Available at: http://www.idf.org/diabetesatlas. Accessed: February 20, 2015.
Guillausseau PJ, Meas T, Virally M, Laloi-Michelin M, Médeau V, Kevorkian JP. Abnormalities in insulin secretion in type 2 diabetes mellitus. Diabetes Metab. 2008;34 Suppl 2:S43–8.
Article
CAS
PubMed
Google Scholar
Park Y, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med. 2003;163:427–36.
Article
PubMed
PubMed Central
Google Scholar
Tavares V, Hirata RD, Rodrigues AC, Monte O, Salles JE, Scalissi N, Speranza RC, Hirata MH. Association between Pro12Ala polymorphism of the PPAR-g2 gene and insulin sensitivity in Brazilian patients with type-2 diabetes mellitus. Diabetes Obes Metab. 2005;7:605–11.
Article
CAS
PubMed
Google Scholar
Stumvoll M, Hans H. The peroxisome proliferator activated receptorγ2 Pro12Ala polymorphism. Diabetes. 2002;51:2341–7.
Article
CAS
PubMed
Google Scholar
Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet. 1998;20(3):284–7.
Article
CAS
PubMed
Google Scholar
Hara K, Okada T, Tobe K, Yasuda K, Mori Y, Kadowaki H, Hagura R, Akanuma Y, Kimura S, Ito C, Kadowaki T. The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun. 2000;217:212–6.
Muller YL, Bogardus C, Beamer BA, Shuldiner AR, Baier LJ. A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians. Diabetes. 2003;52:1864–71.
Article
PubMed
Google Scholar
Meirhaeghe A, Amouyel P. Impact of genetic variation of PPARγ in humans. Mol Genet Metab. 2004;83:93–102.
Article
CAS
PubMed
Google Scholar
Friedewald WT, Levy RI, Frederickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge. Clin Chem. 1972;18:499–502.
CAS
PubMed
Google Scholar
Ereqat S, Nasereddin A, Azmi K, Abdeen Z, Amin R. Impact of the Pro12Ala polymorphism of the PPAR-Gamma 2 gene on metabolic and clinical characteristics in the Palestinian type 2 diabetic patients. PPAR Res. 2009. doi:10.1155/2009/874126.
PubMed
PubMed Central
Google Scholar
Neel JV. The “thrifty genotype” in 1998. Nutr Rev. 1999;57:S2–9.
Article
CAS
PubMed
Google Scholar
Arnaiz-Villena A, Fernandez-Honrado M, Areces C, Enriquez-de-Salamanca M, Abd-El-Fatah-Khalil S, Coca C, Arribas I, Algora M, Rey D. Amerindians show no association of PPAR-γ2gene Ala12 allele and obesity: an “unthrifty” variant population genetics. Mol Biol Rep. 2013;40(2):1767–74.
Article
PubMed
Google Scholar
Ruiz-Narvaez E. Is the Ala12 variant of the PPARG gene an “unthrifty allele”? J Med Genet. 2005;42:547–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gouda HN, Sagoo GS, Harding AH, Yates J, Sandhu MS, Higgins JP. The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol. 2010;171:645–55.
Article
PubMed
PubMed Central
Google Scholar
Scacchi R, Pinto A, Rickards O, Pacella A, De Stefano GF, Cannella C, Corbo RM. An analysis of peroxisome proliferatoractivated receptor gamma (PPAR-gamma 2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits. Nutr Metab Cardiovasc Dis. 2007;17:632–41.
Article
CAS
PubMed
Google Scholar
The International HapMap 3 Consortium. Integrating common and rare genetic variation in diverse human populations. Nature. 2010; 467(7311): 52-58.
Mori H, Ikegami H, Kawaguchi Y, Seino S, Yokoi N, Takeda J, Inoue I, Seino Y, Yasuda K, Hanafusa T, et al. The Pro12→Ala substitution inPPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes. 2001;50:891–4.
Article
CAS
PubMed
Google Scholar
Tai ES, Corella D, Deurenberg-Yap M, Adiconis X, Chew SK, Tan CE, Ordovas JM. Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population. J Lipid Res. 2004;45:674–85.
Article
CAS
PubMed
Google Scholar
Liu XL, Zhang FL, Zhou ZY, Zhao HL, Shen GM, Baohan WY, Duan ZY, Li W, Zhang JW. Analysis of two sequence variants in peroxisome proliferator activated receptor gamma gene in Tajik population at high altitudes and Han population at low altitudes in China. Mol Biol Rep. 2010;37:179–84.
Article
CAS
PubMed
Google Scholar
Oh EY, Min KM, Chung JH, Min YK, Lee MS, Kim KW, Lee MK. Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects. J Clin Endocrinol Metab. 2000;85:1801–4.
CAS
PubMed
Google Scholar
Ben Ali S, Ben Yahia F, Sediri Y, Kallel A, Ftouhi B, Feki M, Elasmi M, Haj-Taieb S, Souheil O, Sanhagi H, Slimne H, Jemaa R, Kaabachi N. Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Clin Biochem. 2009;42:1642–7.
Article
CAS
PubMed
Google Scholar
Badii R, Bener A, Zirie M, Al Rikabi A, Simsek M, Al Hamaq AO, Ghoussaini M, Froquel P, Wareham NJ. Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2gene and type 2 diabetes mellitus in the Qatari consanguineous population. Acta Diabetol. 2008;45(1):15–21.
Article
CAS
PubMed
Google Scholar
Sanghera DK, Ortega L, Han S, Singh J, Ralhan SK, Wander GS, Mehra NK, Mulvihill JJ, Ferrel RE, Nath SK, Kamboh MI. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala) IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet. 2008;9:59.
Article
PubMed
PubMed Central
Google Scholar
Costa V, Casamassimi A, Esposito K, Villani A, Capone M, Iannella R, Shisano B, Ciotola M, Di Palo C, Corrado FC, Santangelo F, Giugliano D, Ciccodicola A. Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy. J Biomed Biotechnol. 2009;2009:126917.
Article
PubMed
PubMed Central
Google Scholar
Gonzalez Sanchez JL, Serrano RM, Fernandez PC, Laakso M, Martinez Larrad MT. Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population. Eur J Endocrinol. 2002;147(4):495–501.
Article
CAS
PubMed
Google Scholar